Dinor Casearin X, a New Cytotoxic Clerodane Diterpene from Casearia sylvestris

AUTOR(ES)

Bou, Diego D., Santos, Augusto L. dos, Figueiredo, Carlos R., Farias, Camyla F., Matsuo, Alisson L., Kitamura, Rodrigo O. S., Gimenes, Leila, Lago, João H. G., Sartorelli, Patricia

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-08

RESUMO

A new clerodane-type diterpene, named dinor casearin X, and four known casearins (A, B, G and J) were isolated from leaves of Casearia sylvestris(Salicaceae). These compounds were evaluated for cytotoxic activity against five human cancer cell lines (A2058, HL-60, HCT, MCF-7 and HeLa) as well as against a murine melanoma cell line (B16F10-Nex2). Among these compounds, dinor casearin X exhibited the highest cytotoxic activity against HL-60 cells with IC₅₀ of 0.51 ± 0.11 µg mL^-1, whereas casearin A exhibited the highest cytotoxic activity against HCT cells (IC₅₀ 1.84 ± 0.14 µg mL^-1).

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