Dimensões das vias aéreas na asma fatal e na doença pulmonar obstrutiva grave / Airway dimensions in fatal asthma and severe COPD

AUTOR(ES)

Aletéa Senhorini

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

15/09/2011

RESUMO

Background: In some patients with chronic asthma, clinical and physiological similarities with chronic obstructive pulmonary disease may co-exist, such as partial reversibility to bronchodilators despite persistent expiratory airflow obstruction. However, pathologic analyses comparing both diseases in patients of similar age and disease severity are scarce. Methods: We compared the large and small airway dimensions in 12 younger (mean±SD, age 32 yr±3 yr) and 15 older (65 yr±1 yr) non-smoking fatal asthmatics with 14 chronic smokers with severe, fatal COPD (71 yr±1 yr) and 19 control patients (56 yr±1 yr). Using H&E, Movat\ s pentachrome staining and image analysis, we quantified large airway basement membrane (BM) thickness (?m); submucosal gland area; and large and small airway inner wall, smooth muscle and outer wall areas. Areas were normalized by BM perimeter (?m2/?m). Results: Younger adult fatal asthmatics had thicker BM, smooth muscle, and outer wall areas in both small and large airways when compared to agematched controls and fatal COPD patients. In older asthmatics, there was an overlap in BM thickness and submucosal gland area, whereas both large and small airway smooth muscle areas were thicker compared to age-matched controls and fatal COPD patients. COPD patients had thinner large and small airway smooth muscle areas compared to age-matched controls. Younger asthmatics had thicker small airway smooth muscle area compared to older asthmatics. Conclusion: Our data provide novel pathological substrate changes that may help us better understand physiological similarities and differences in younger and older patients with asthma compared to COPD.

ASSUNTO(S)

asma/patologia asthma/pathology autopsia autopsy basement membrane/pathology chronic obstructive pulmonary disease/pathology doença pulmonar obstrutiva crônica/patologia membrana basal/patologia músculo liso/patologia smooth muscle/pathology

Documentos Relacionados

• SPI2 GENE POLIMORPHISM IN RECURRENT AIRWAY OBSTRUCTION AND INFLAMMATORY AIRWAY DISEASE IN THOROUGHBRED HORSES
• Severe obstructive disease : similarities and differences between patients with chronic obstructive pulmonary disease (COPD) and/or bronchiectasis
• Innate immunity in fatal asthma
• Depressão e ansiedade em pacientes com asma e doença pulmonar obstrutiva crônica
• Exacerbação da asma e infecção das vias aéreas: o vírus é o vilão?