Dieta normocalórica de ácidos graxos de cadeia média: Efeitos sobre a secreção de insulina, tecido adiposo e fígado de ratos jovens / Medium chain fat acid normocaloric diet: effects upon insulin secretion, adipose tissue and liver of young rats

AUTOR(ES)

Anderson Carlos Marçal

DATA DE PUBLICAÇÃO

2009

RESUMO

The introduction of MCFA into diet induces insulin resistance, reduced body weight gain, and increased adiposity in Wistar rats. Isolated adipocytes have reduced insulin induced glucose uptake and phosphorylation/activation of AMPK protein. The insulin receptor protein expression is increased in liver of MCFA fed rats accompanied by reduced tyrosine phosphorylation, with similar AKT serine phosphorylation. Isolated pancreatic islets had reduced glucose stimulated insulin secretion due to high glucose exposure and reduced insulin content; higher insulin secretion induced by leucine and arginine, and increased apoptosis with reduced AKT protein level. In these regard, the chronic ingestion of MCFA may interfere with normal body growth, with the insulin sensitivity and may participate with the development of diabetes.

ASSUNTO(S)

intracellular signaling resistência à insulina agcm tecido adiposo insulin receptor ilhotas pancreáticas adipose tissue sinalização intracelular insulin resistance receptor para insulina pancreatic islets mcfa

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