Dieta hiperlipidica e frequencia de ingestão alimentar : efeitos sobre as reservas lipidicas e a tolerancia a glicose em ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

Fat diets (HL) are risk factor for metabolic diseases. Frequent feeding (nibbling pattern) may prevent these disorders, and meal feeding (gorging) may cause obesity and insulinemia peaks. The aim of this study was to evaluate obesity and glucose intolerance development, and serum lipids in rats submitted to different feeding frequencies associated to HL (39% fat) and control diet (11%). Female Wistar rats were accompanied during 8 weeks divided into: CG (gorging control, one meal a day with stock diet for 2h1day); BLG (gorging fat, one meal a day with fat rich diet for 2h1day); CN (nibbling control, 24h1d access to stock diet); BLN (nibbling fat, 24h1d access to fat rich diet). Food intake was limited in order to match the energy intake among all groups. OGTT (Oral glucose tolerance test), adipose tissue dissection, lipid extraction, plasma and glycogen analyses were performed. HL animals were heavier and fatter than controls. Lipid incorporation into carcass fat were greater in CG (88,1 i: 21,0 mg/g) than CN (55,7 i: 11,2 mg/g), however BLG (101,9 i: 19,2 mg/g) and BLN (101,3:t 14,3 mg/g) had the same fat amount in body carcass. CG and CN had more musc1e glycogen content than BLG and BLN. Gorging groups showed heavier liver glycogen deposit. There were no differences in insulinemia, cholesterolemia, serum albumin and serum HDL-cholesterol, but BLG had the greatest basal serum glucose. OGTT showed greater glucose concentrations in HL animals than in controls. There was glucose tolerance impairment in gorging rats. Meal feeding increased the rate of fat deposition when the low-fat diet is given, but did not improve the already efficient utilization of the high-fat diet. The association between HL and gorging induced glucose tolerance impairment. Future studies are important to better understand the metabolic syndrome evolution consequent to these feeding behaviors

ASSUNTO(S)

jejum testes de tolerancia a glicose lipidios na nutrição humana

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