"Determinantes morfológicos do efeito do ácido ascórbico na isquemia/reperfusão experimental do intestino delgado" / Morphological determinants of ascorbic acid effect in an experimental small bowel ischemia/reperfusion

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Intestinal injury resulting from ischemia-reperfusion (I/R) is of fundamental importance in surgical procedures. Some oxygen-derived free radicals generated during this time possibly play an important role. We used ascorbic acid to attenuate I/R injury. Fifty male rats were divided into five groups, each containing 10 rats. The groups were submitted to mesenteric ischemia and ischemia/reperfusion, experimental groups received ascorbic acid. The intestinal histological morphometric analysis was performed. The ascorbic acid groups showed a significant reduction of antimesenteric villous infarct (p=0,009) in the /R and reduction of villous necrosis ischemia groups. The ascorbic acid is effective in reducing the intestinal damage caused by I/R in the rats

ASSUNTO(S)

isquemia/cirurgia Ácido ascÓrbico reperfusion intestine small ratos wistar histological techniques reperfusÃo tÉcnicas histolÓgicas ischemia/chirurg rats wistar ascorbic acid intestino delgado

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