Detecção do citomegalovirus em fragmento hepatico de pacientes com colestase neonatal extra-hepatica por meio da reação em cadeia da polimerase

AUTOR(ES)

Adriana Maria Alves De Tommaso

DATA DE PUBLICAÇÃO

2002

RESUMO

Colesthasis is the reduction or the interruption of the bile flow to the duodenun. The classification in causes intrahepatic and extrahepatic is very important, being the biliary atresia (BA) the major cause ofthe later. BA is the most severe hepatic disorder in newborns and its etiopathogenesis remains unknown. Viral involvement has been proposed, including the cytomegalovirus (CMV). CMV infection occurs in 1-2% of the newborns and is assymtomatic in more than 90% of the cases. The transmission to the fetus is greater in the primary maternal infection, although a recurrent infection account for the majority of the congenital infections. Laboratory diagnosis is made by serologic methods or by isolation of the virus in fibroblast cell culture. The amplification of DNA by the polymerase chain reaction (PCR) makes possible the diagnosis in specimens with few copies ofthe virus...Note: The complete abstract is available with the full electronic digital thesis or dissertations

ASSUNTO(S)

biologia molecular ictericia neonatal

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