Desenvolvimento de sonda gama para cirurgia radioguiada

AUTOR(ES)

Iran Josà Oliveira da Silva

DATA DE PUBLICAÇÃO

2008

RESUMO

The use of intraoperative methods for guiding surgeries is increasing and is a promising method for improving the effectiveness of the surgical treatment of cancer. The procedure begins before surgery with the administration of a tumor-avid pharmaceutical that, usually, is labeled with a g-ray emitting radionuclide. During the subsequent surgical procedure, a handheld g−ray sensitive probe is used to survey regions of suspected disease to localize areas of increased tracer uptake, and therefore sites of potential tumors cells. In this paper we present the response of a new gamma probe developed to be used for radioimmunoguided surgery. This probe, SGHI-01, consists of a plastic scintillation detector coupled to a light guide with 60mm of length, that was coupled to a photomultiplier tube, that was connected to an electronic system. The following tests were made to evaluate the performance of the g-probe SGHI-01: evaluation of the probe response for point sources in function of the distance between the source and the probe, energy spectra for Am-241 and Tc-99m, energy resolution and resolution to separate two radioactive sources with different activities. The response of the probe SGHI- 01 was compared with the response of EUROPROBE, a commercial g-probe. The results showed that the better detection efficiency is obtained with a plastic scintillation detector re-covered with teflon and with 10 cm of length and 7.5cm of diameter. It was also observed a linear response of the SGHI-01 gamma probe in function of the source activity. It was also observed that the spatial resolution of the SGHI-01 is adequate to separate two radioactive sources with a activity rate of 40:1, separated by 4cm. The response of the SGHI-01 probe is similar of the EUROPROBE, making patent that the SGHI-01 can be used for radioimmunoguided surgery

ASSUNTO(S)

sonda gama radioimmunoguided surgery gamma probe sentinel lymph node engenharia nuclear cirurgia radioguiada linfonodos sentinelas

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