"Contribuição ao estudo da influência da radiação ionizante pré-operatória sobre a marcação do linfonodo sentinela do reto com azul patente: estudo experimental em ratos" / Contribution to the study of the influence of preoperative ionizing radiation on the identification of the sentinel lymph node with patent blue : an experimental study in rats

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Previous ionizing radiation induces actinic alterations in peritumoral tissues and thus might influence the localization of the sentinel lymph node. The present study developed an experimental model for the localization of the sentinel lymph node of the rectum of the rat and for the definition of the dose of radiation (calibration curve). The objective was to evaluate the influence of preoperative ionizing radiation on the staining of a patent blue dye in the sentinel lymph node of the rectum in rats.The sample was composed of 40 male Wistar rats and was divided in two groups: Group 1 (non-irradiated control; n = 20 ) and Group 2(irradiated with 1200cGy and stained 2 days afterwards; n = 20). It was observed a linear increase in the time for the staining of the lymph in Group 2.In conclusion, preoperative irradiation did not influence the staining of the sentinel lymph node of the rectum in rats

ASSUNTO(S)

linfonodo/irrigação sangüínea metástase linfática/diagnóstico mapeamento por restrição/métodos restriction mapping/methods neoplasias retais/irrigação sangüínea radiação ionizante radiation ionizing lymphatic metastasis/diagnosis rectal neoplasms/blood supply rectal neoplasms/radioterapy sentinel lymph node biopsy/methods lymphatic metastasis/radiotherapy dyes/diagnostic use neoplasias retais/radioterapia linfonodo/efeitos de radiação ratos wistar biópsia de linfonodo sentinela/métodos lymph/radionuclide imaging linfonodo/cintilografia rats wistar tinturas/uso diagnóstico metástase linfática/radioterapia

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