"Computational simulations biologically plausible of neurons of the primary somatosensory cortex" / "Simulações computacionais biologicamente plausíveis de neurônios do córtex somestésico primário"
AUTOR(ES)
Rubens Antonio Condeles Júnior
DATA DE PUBLICAÇÃO
2006
RESUMO
Since its appearance, the computer has been used to model phenomena in all areas of knowledge. In neuroscience, computer modeling is used to describe, reproduce and predict behaviors of different components of the nervous system. As well as in other areas of sciences, this procedure has been shown to be efficient in the study and improvement of theories on brain function. With the increasing power of computers, larger and more detailed models can be constructed with an increasing degree of biological realism. In this work, we present biologically plausible computer models of cortical neurons from the primary somatosensory system. The models have been implemented based on the Hodgkin-Huxley formalism for ionic channels and the Rall´s compartmental technique for spatial extent. The parametrs have been adjusted based on in vivo and in vitro experimental results taken from the literature. Simulation results have shown that the models are biologically acceptable and of superior quality in comparison with previous models, allowing the construction of more precise large-scale neuronal network models.
ASSUNTO(S)
phase-space modelagem computacional computational neuroscience neurônio neurociência computacional espaço de fase neuron
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