Comparative study between two main obtaining routes of the Megazol / Comparação das duas principais rotas de obtenção do megazol

AUTOR(ES)

Fabricio Soares Arantes

DATA DE PUBLICAÇÃO

2007

RESUMO

The scope of the present work is the analogy study over the two main routes on megazol synthesis, based on studies previously accomplished at the College of Pharmaceutical Sciences of USP. In the results of the above referred studies, it was observed that the obtaining of the megazol can be achieved by different synthetic ways, by modifying processes and reagents related to the chemical properties of heterocyclic compounds, particularly with the imidazoles. Experimental conditions, both partial and final yields as well as the characteristics of the reagents evolved in the indicated processes were evaluated.

ASSUNTO(S)

comparação de rotas routes comparison toxicidade de reagentes drug synthesis antichagásicos megazol toxicity of reagents fármacos sintéticos síntese de fármacos composto heterocíclico planejamento de fármacos megazol antiparasitários

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