Cognitive impairment and oncologic pain treatment. / "Alteração cognitiva e o tratamento da dor oncológica"

AUTOR(ES)

Geana Paula Kurita

DATA DE PUBLICAÇÃO

2006

RESUMO

The cognitive functions of patients in oncologic pain treatment were assessed three times, over the period of a month. The performance of patients in treatment with opioids (Group Receiving Opioids – GRO, n=14) was compared with that of a group of patients receiving treatment without the administration of opioids (Group Without Opioids – GWO, n=12). Relations between cognitive function, pain intensity and opioid dose were also analysed. The cognitive function was assessed by the Trail Making Test, Mini-mental State Examination, Digit Span Test, Brief Cognitive Screening Battery and Beck Depression Inventory. In order to identify statistical differences, the significance level was established in 5%. The longitudinal analysis to the GWO showed improvement in incidental recall (P=0,005) and learning (P=0,016); however, deterioration in the constructional and visuoperceptual abilities was noticed (P=0,039). Improvement was observed in the incidental recall (P=0,038) of the GRO. In both groups there were no changes in the Trail Making Test, Mini-mental State Examination, Digit Span Test, Beck Depression Inventory and other tests from Brief Cognitive Screening Battery. The comparison between groups showed that GWO had better performance in attention/concentration, working memory (P=0,029) and also in executive functions (P=0,023). The analyses of the correlations in GRO demonstrated that less intense pain corresponds to higher scores in Mini-mental State Examination (P =0,001), in incidental recall (P=0,030 e P =0,014), in immediate recall (P=0,042) and in delayed recall (P=0,037) assessed by the Brief Cognitive Screening Battery. No correlations were observed in GWO. There was no correlation between opioid dose and performance in the results. In the longitudinal tests and comparative analyses between the groups, GWO had better performance than GRO. However, this superiority was not verified in the three assessments, as well as in the case of the majority of the tests results. The negative correlation between pain intensity and cognitive function on the group receiving opioids indicated that pain intensity had an influence on cognitive performance. Further research is necessary to broaden the knowledge about this issue.

ASSUNTO(S)

cognition opioids opióides transtornos cognitivos atenção/concentração cognição memória attention/concentration pain neoplasias/câncer memory cognitive disorders dor neoplasms/cancer

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