Chemical investigation of Spigelia anthelmia Linn. used in Brazilian folk medicine as anthelmintic
AUTOR(ES)
Morais, Selene Maia de, Beviláqua, Cláudia Maria Leal, Souza, Júlia Aprecida L. de, Assis, Luciana Moura de
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
2002
RESUMO
An ethanol extract of aerial parts of Spigelia anthelmia was submitted to vacuum column chromatography being eluted with hexane, chloroform, ethyl acetate and methanol. The four extracts were assayed for anthelmintic activity against Haemonchus contortus, the main nematode in caprines. The ethyl acetate extract showed the strongest anthelmintic activity and the chemical study of this extract revealed as main constituents the alkaloid spiganthine and 3,7-dihydroxy-3',4'- dimethoxyflavone.
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