Chemical constituents from Bauhinia acuruana and their cytotoxicity
AUTOR(ES)
Góis, Roberto W.S., Sousa, Leôncio M. de, Silva, Horlando C. da, Silva, Francisco E.F. da, Pimenta, Antonia T.A., Lima, Mary A.S., Arriaga, Angela M.C., Lemos, Telma L.G., Braz-Filho, Raimundo, Militão, Gardenia C.G., Silva, Paulo B.N. da, Gonçalves, Francisco J.T., Santiago, Gilvandete M.P.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2017-12
RESUMO
ABSTRACT Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2'-hydroxy-2,3,5-trimethoxybibenzyl (1), (2R,3S)-2-(3,4'-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol (2), together with fourteen known ones (3–16). The structures of the compounds were established by spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR data, followed by comparison with previously reported data from the literature. Compounds 1, 2, 6, 7, 8 and 9 were evaluated for their cytotoxicity, which turned out to be marginal in a panel of six human cancer cell lines.
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