Challenges in Pharmacological Management of Cardiovascular Diseases in Covid-19: do Benefits Outweigh Risks?
AUTOR(ES)
Pedro, Samuel de Sousa; Brito, Fernanda Carla Ferreira de; Scaramello, Christianne Bretas Vieira
FONTE
Int. J. Cardiovasc. Sci.
DATA DE PUBLICAÇÃO
2020-07
RESUMO
In this study we have expanded upon a family of substituted pentacyclic oxadiazadiborinane derivatives from the condensation of carbohydrazide with ortho-formylphenyl boronic acid derivatives containing a variety of chemical and physical properties. All new complexes have been characterized fully including two single crystal X-ray diffraction studies which confirm the solid-state structure of these species along with an unusual methanol activation product, which appears to be a minor solid-state side product. The lack of inherent solubility of these compounds in common physiological media precluded us from doing traditional antimicrobial activities. To circumvent this problem, we incorporated these boron compounds into chitosan films. Only weak or moderate activities against Gram-negative and Gram-positive bacteria were observed in this study.
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