Carotid Artery Brain Aneurysm Model: In Vivo Molecular Enzyme-specific MR Imaging of Active Inflammation in a Pilot Study1

AUTOR(ES)

DeLeo, Michael J.

FONTE

Radiological Society of North America

RESUMO

In this article, we have described an animal model of saccular aneurysm inflammation that can be depicted with clinical-field-strength MR imaging and use of the enzyme-sensitive MR contrast agent di-5-hydroxytryptamide of gadopentetate dimeglumine, which is a paramagnetic myeloperoxidase substrate that enhances MR signal in an enzyme-specific manner.

Documentos Relacionados

• Enzyme-specific profiles for genome annotation: PRIAM
• Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
• Tissue Doppler imaging of carotid plaque wall motion: a pilot study
• Atherosclerosis and Matrix Metalloproteinases: Experimental Molecular MR Imaging in Vivo
• Aneurysm of the rabbit common carotid artery induced by periarterial application of calcium chloride in vivo.