Atherosclerosis and Matrix Metalloproteinases: Experimental Molecular MR Imaging in Vivo

AUTOR(ES)

Amirbekian, Vardan

FONTE

Radiological Society of North America

RESUMO

Purpose: To evaluate the capability of P947, a magnetic resonance (MR) imaging contrast agent that molecularly targets matrix metalloproteinases (MMPs), to aid detection and imaging of MMPs in atherosclerotic lesions in vivo; its specificity compared with that of P1135; expression and distribution of MMPs in atherosclerotic vessels; and in vivo distribution and molecular localization of fluorescent europium (Eu) P947.

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