Caracterização molecular de Vírus Respiratório Sincicial Humano (HRSV) isolados na cidade de São Paulo no período de 2007 a 2008. / Characterization and epidemiologic of Human Respiratory Syncytial Virus (HRSV) isolated in São Paulo city in 2007-2008.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Human Respiratory Syncytial Virus (HRSV) is considered the most common cause of lower respiratory tract disease in infants and young children and are the main guilty for the elevated children hospitalizations rate under 5 years of age. The HRSV has a world-wide distribution, being able to attack all the ages however the 6 weeks to 9 months children of are the ones that develop more serious problems as pneumonia and bronquiolite. The HRSV outbreak presents a well defined season, occurring annually in the delayed falls period, winter or springs beginning, but not during the summer. In the present study, we performed a phylogenetic analysis from G2 region of HRSV G glycoprotein. Forty four samples positive for HRSV from University Hospital (UH) of University of Sao Paulo (USP) in 2007-2008, were submitted to sequencing by PCR and compared with GenBank sequences. Phylogenetic analysis revealed that HRSV group A genotypes GA2 and GA5 was the predominant in 2007-2008, alternating the standard verified in the previous years, where the group B genotypes had been highly predominant. Comparison of the synonymous/nonsynonymous mutation ratios showed greater evidence for positive selection pressure for group A genotypes GA2 and GA5.

ASSUNTO(S)

glicoproteínas g vírus respiratório sincicial humano phylogeny (analysis) respiration human respiratory syncytial virus inserção de 60 nucleotídeos filogenia (análise) infecções respiratórias genetic variation g2 region g glycoproteins respiratory infections variação genética região g2 60 nucleotide duplication respiração

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