Bronchial dysplasia induced by radiation in miners exposed to 222Rn progeny.
AUTOR(ES)
Michaylov, M A
RESUMO
OBJECTIVES--To investigate whether sputum cytology can be used to monitor epithelial cell changes in groups at high risk of lung cancer from exposure to radiation. METHODS--Dysplasia of bronchial cells was investigated by means of sputum cytology in a group of 434 underground miners. 100 of them were not exposed, and 334 were exposed to 222Rn progeny at cumulative exposures < 450 working level months. RESULTS--The frequency of dysplasia in the exposed group was significantly higher than that in the not exposed group (P < 0.0001), and an exposure-response relation was found. This relation was different for smokers and non-smokers. CONCLUSIONS--Possibly the frequencies of dysplasia could be used to assess past exposures of groups of miners. This approach could be applied to cases where data on radiation monitoring are not available or are very scarce.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1128159Documentos Relacionados
- Mutation rates at the glycophorin A and HPRT loci in uranium miners exposed to radon progeny.
- alpha-Radiation dose at bronchial bifurcations of smokers from indoor exposure to radon progeny.
- Avaliação da exposição ocupacional ao 222Rn no galpão da salvaguardas do IPEN
- Dosimetria gama e concentração de 222Rn em ambientes de trabalho fechados da cidade de São Paulo
- Avaliação da exposição ao ²²²Rn nas cavernas do Parque Estadual Turístico do Alto Ribeira (PETAR)