beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
Hammonds, R G
beta h-Endorphin-(1-27), a naturally occurring fragment of human beta-endorphin (beta h-endorphin), diminishes the analgesic effect of beta h-endorphin when coinjected intra-cerebroventricularly into mice. A parallel shift in the dose-response curve of beta h-endorphin in the presence of beta h-endorphin-(1-27) suggests competition at the same site. The potency of beta h-endorphin-(1-27) in antagonizing analgesia is greater than 4 times greater than that of the opiate antagonist naloxone.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=344839
- Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.
- beta-endorphin is a potent analgesic agent.
- beta-Endorphin enhances lymphocyte proliferative responses.
- beta-Endorphin induces nonconvulsive limbic seizures.
- beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.