beta-endorphin is a potent analgesic agent.
Loh, H H
beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=430793
- beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
- beta-Endorphin enhances lymphocyte proliferative responses.
- beta-Endorphin induces nonconvulsive limbic seizures.
- Presence of immunoreactive beta-endorphin in normal human plasma: a concomitant release of beta-endorphin with adrenocorticotropin after metyrapone administration.
- Immunoreactive beta-endorphin in a subpopulation of mouse spleen macrophages.