Avaliação do efeito da infecção por Helicobacter pylori na expressão das citocinas pró-inflamatórias IL-1β, IL-8 e COX-2./ / Helicobacter pylori; IL-1β 3.IL-8 4.COX-2

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

28/07/2010

RESUMO

The infection caused by Helicobacter pylori has been considered as one of the most common chronic bacterial infections in humans. The infection causes an inflammatory response that is followed by an increase in the production of cytokines. Thus, the aim of this study was to evaluate the effects of infection by H. pylori upon gene expression of pro-inflammatory cytokines IL-1b, IL-8 and COX-2 in children H. pylori-positive and negative as well as in adult H. pylori-positive and negative chronic gastritis and gastric cancer patients. The study included 344 patients, divided into five groups: (1) 29 children with H. pylori positive, (2) 98 children with H. pylori negative, (3) 127 adult H. pylori positive, (4) 26 adult H. pylori negative and (5) 64 patients with gastric cancer. Our data indicate that the infection is related to a risk of developing gastric cancer (OR = 4.21, 95% CI = 1.41 ≤ m ≤ 12:55, r = 0.01). Regarding the virulence factors vacA, iceA and babA in children, we did not observe the prevalence of any of the factors studied in this sample. However, it was observed an increase on infection with cagA- strains among this population. Moreover, in adults it was found that infection by more virulent strains (cagA + / vacAs1m1) is a risk factor for developing gastric cancer. By analyzing the expression of pro-inflammatory cytokines IL-1β, IL-8 and COX-2, the data shown in this study showed no differences in the expression of these regardless of the presence of bacteria. Moreover, in adults with chronic gastritis, there was a significant increase in the expression of these genes, and furthermore, these values are even higher in patients infected with cagA-positive strains, vacA s1m1. In patients with gastric cancer was a significant reduction of IL-1β and IL-8, probably due to low bacterial density in biopsies derived from these patients. For COX-2 has not detected a reduction in mRNA levels in these patients.

ASSUNTO(S)

helicobacter pylori il-1β 3.il-8 4.cox-2 pediatria effect of helicobacter pylori infection on the expression of the pro-inflammatory cytokines il-1β , il-8 and cox-2.

ACESSO AO ARTIGO

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