Il 8 And Cox 2
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. [RETRACTED ARTICLE] Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death of chondrocytes; therefore, finding an effective and non
Braz J Med Biol Res. Publicado em: 12/08/2019
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2. microRNA-142-3p inhibits apoptosis and inflammation induced by bleomycin through down-regulation of Cox-2 in MLE-12 cells
microRNA (miR)-142-3p is implicated in malignancy and has been identified as a biomarker for aggressive and recurrent lung adenocarcinomas. This study aimed to evaluate the inhibitory effect of miR-142-3p on apoptosis and inflammation induced by bleomycin in MLE-12 cells. MLE-12 cells were first transfected either with miR-142-3p mimic or miR-142-3p inhibito
Braz J Med Biol Res. Publicado em: 03/07/2017
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3. Terapia laser de baixa intensidade a 808 nm reduz a resposta inflamatória e favorece a regeneração muscular
Muscle regeneration is a complex phenomenon, involving coordinated activation of several cellular responses. During this process, oxidative stress, and consequent tissue damage occur with a severity that may depend on the intensity and duration of the inflammatory response. Among the therapeutic approaches to attenuate inflammation and increase tissue repair
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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4. Avaliação do efeito da infecção por Helicobacter pylori na expressão das citocinas pró-inflamatórias IL-1β, IL-8 e COX-2./ / Helicobacter pylori; IL-1β 3.IL-8 4.COX-2
The infection caused by Helicobacter pylori has been considered as one of the most common chronic bacterial infections in humans. The infection causes an inflammatory response that is followed by an increase in the production of cytokines. Thus, the aim of this study was to evaluate the effects of infection by H. pylori upon gene expression of pro-inflammato
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2010
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5. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells
Cyclooxygenase-2 (COX-2) expression is normally tightly regulated. However, constitutive overexpression plays a key role in colon carcinogenesis. To understand the molecular nature of enhanced COX-2 expression detected in colon cancer, we examined the ability of the AU-rich element–containing (ARE-containing) 3′ untranslated region (3′UTR) of COX-2 mRN
American Society for Clinical Investigation.
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6. Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells.
Interleukin 1 and nitric oxide (NO) from infiltrating macrophages and activated mesangial cells may act in concert to sustain and promote glomerular damage. To evaluate if such synergy occurs, we evaluated the effect if IL-1 beta and NO on the formation of prostaglandin (PG)E2 and cyclooxygenase (COX) expression. The NO donors, sodium nitroprusside and S-nit
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7. Differences in signaling pathways by IL-1β and IL-18
IL-1 and IL-18 are members of the IL-1 family of ligands, and their receptors are members of the IL-1 receptor family. Although several biological properties overlap for these cytokines, differences exist. IL-18 uniquely induces IFN-γ from T lymphocytes and natural killer cells but does not cause fever, whereas fever is a prominent characteristic of IL-1 in
National Academy of Sciences.
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8. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis
Prostaglandin E synthase (PGES) including isoenzymes of membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES) is the recently identified terminal enzyme of the arachidonic acid cascade. PGES converts prostaglandin (PG)H2 to PGE2 downstream of cyclooxygenase (COX). We investigated the expression of PGES isoenzyme in articular chondrocytes fr
BioMed Central.
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9. Porphyromonas gingivalis Gingipain-R Enhances Interleukin-8 but Decreases Gamma Interferon-Inducible Protein 10 Production by Human Gingival Fibroblasts in Response to T-Cell Contact
Proteases produced by Porphyromonas gingivalis, an oral pathogen, are considered important virulence factors and may affect the responses of cells equipped with proteinase-activated receptors. The aim of this study was to investigate the effect of the arginine-specific cysteine protease gingipain-R produced by P. gingivalis on chemokine production by human g
American Society for Microbiology.
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10. Host Response to Infection: the Role of CpG DNA in Induction of Cyclooxygenase 2 and Nitric Oxide Synthase 2 in Murine Macrophages
Depending on sequence, bacterial and synthetic DNAs can activate the host immune system and influence the host response to infection. The purpose of this study was to determine the abilities of various phosphorothioate oligonucleotides with cytosine-guanosine-containing motifs (CpG DNA) to activate macrophages to produce nitric oxide (NO) and prostaglandin E
American Society for Microbiology.
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11. Effects of Nonsteroidal Anti-Inflammatory Drugs on Helicobacter pylori-Infected Gastric Mucosae of Mice: Apoptosis, Cell Proliferation, and Inflammatory Activity
Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) are two well-known important causative factors of gastric damage. While H. pylori increases apoptosis and the proliferation of gastric epithelial cells and is an important factor in peptic ulcer and gastric cancer, NSAIDs induce cell apoptosis and have antineoplastic effects. We investigat
American Society for Microbiology.
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12. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells
Cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E2 (PGE2) plays a key role in inflammation and its associated diseases, such as cancer and vascular heart disease. Here we report that γ-tocopherol (γT) reduced PGE2 synthesis in both lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and IL-1β-treated A549 human epithelial cells wit
The National Academy of Sciences.