Avaliação de metaloproteinases e de marcadores inflamatorios em pacientes com sindrome metabolica / Assesment of metaloproteinases and pro-inflammatory markers in patients with metabolic syndrome

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The metabolic syndrome (MetS) denotes a clustering of cardiovascular and diabetes risk factors. The metalloproteinase (MMPs) are enzymes involved in maintaining the homeostasis of the extracellular matrix and an imbalance between their concentrations and their endogenous inhibitors (TIMPs) may play important role in the cardiovascular modifications associated with MetS. In addition, a chronic inflammatory state has been described in patients with MetS, thus leading to the development of atherosclerosis. We hypothesized that increased concentrations of pro-inflammatory mediators and imbalanced concentrations of matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) may reflect the pathophysiology of MetS. To address this issue, we studied 25 healthy subjects and 25 MetS patients. The plasma levels of pro-MMP-2 and pro-MMP-9 were determined by gelatin zymography. The plasma concentrations of MMP-8, MMP-3, TIMP-1, TIMP-2, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), intercellular adhesion molecule (sICAM-1), and sP-selectin were measured by ELISA kits. The results revealed an increase in sP-selectin, sICAM-1, MCP-1, IL-6, pro-MMP-9, MMP-8, and TIMP-1 in MetS patients compared with healthy controls. In addition, no differences in pro-MMP-2, MMP-3, and TIMP-2 levels were found. These findings suggest that MMPs may have a role in the increased cardiovascular risk of MetS patients and pharmacological interventions targeting MMPs, especially MMP-9 and MMP-8 deserve further investigation in MetS patients

ASSUNTO(S)

metalloproteases metaloproteinase marcadores inflamatorios metabolic syndrome sindrome metabolica inflammatory markers

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