Avaliação das lesões teciduais hepaticas durante isquemia fria apos perfusão com analogo de prostaglandina E1 : estudo experimental em ratos
AUTOR(ES)
Henrique Jose Virgili Silveira
DATA DE PUBLICAÇÃO
2003
RESUMO
The effect of prostaglandin El analogue in hepatic injury during cold ischenúa were evalueted in this study. The objective to verifY if occur attenuation in the ischemic liver damage. Thirty male rats were divided in two groups of 15 animaIs each: control, where was perfunded with University of Wisconsin solution and test group, which was perfunded with this solution added of prostaglandin El analogue (misoprostol). Biopsies were obtained immediately after perfusion and with 12, 18 and 24 hours after the perfusion. The variables analysed were tissular edema, hidropic changes, fatty changes, endothelium injury, bile duct injury, necrosis and inflammatory processo The Mann- Whitney test for non-parametric variables was used to compare the samples. In the period of 12 and 18 hours no statistical difIerences were found in biopsies. In the period of 24 hours necrosis, endothelium injury and inflammatory process were significant1y more (p <0,001) in control group. The author conc1ued that utilization of prostaglandin E 1 analogue in hepatic perfusion has a protective effect ofhepatic tissue injury during prolongated storage. The effect of prostaglandin El analogue in hepatic injury during cold ischenúa were evalueted in this study. The objective to verifY if occur attenuation in the ischemic liver damage. Thirty male rats were divided in two groups of 15 animaIs each: control, where was perfunded with University of Wisconsin solution and test group, which was perfunded with this solution added of prostaglandin El analogue (misoprostol). Biopsies were obtained immediately after perfusion and with 12, 18 and 24 hours after the perfusion. the variables analysed were tissular edema, hidropic changes, fatty changes, endothelium injury, bile duct injury, necrosis and inflammatory processo The Mann- Whitney test for non-parametric variables was used to compare the samples. In the period of 12 and 18 hours no statistical difIerences were found in biopsies. In the period of 24 hours necrosis, endothelium injury and inflammatory process were significant1y more (p <0,001) in control group.The author conc1ued that utilization of prostaglandin E 1 analogue in hepatic perfusion has a protective effect ofhepatic tissue injury during prolongatedstorage
ASSUNTO(S)
transplante de orgãos - tecido preservação figado
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000298900Documentos Relacionados
- Os efeitos da prostaglandina E1 e da n-acetilcisteína na preservação hepática durante a fase de isquemia fria usando a solução UW : estudo experimental em ratos
- Avaliação metabólica das lesões de isquemia e reperfusão cerebrais após oclusão bilateral das artérias carótidas comuns: estudo experimental em ratos
- Analise de aspectos morfologicos atraves da tecnica de Hanssen modificada e avaliação de fluxos de perfusão durante a conservação renal com diferentes soluçõesde perfusão : estudo experimental em ratos
- Metabolismo dos corpos cetônicos durante as lesões de isquemia e reperfusão cerebrais após oclusão bilateral das artérias carótidas comuns em ratos
- Influência do antibiótico nas lesões de isquemia e reperfusão intestinal: estudo experimental em ratos