Avaliação da microalbuminuria e da alfa-1 microglobulina em pacientes soro-positivos para hepatite C

AUTOR(ES)
DATA DE PUBLICAÇÃO

2000

RESUMO

One hundred and four individuals found to be serurn-positive for hepatitis C during blood donation, were evaluated for microalbuminuria (for evaluation of glomerular proteinuria) and urinary alpha-1micro- globulin excretion (for evaluation of tubular proteinuria). All were asymptomatic and presented normal renal and hepatic function, normal urine sedimentation and absence of macroproteinuria. While practica1ly a1l (98.1 %) presented normallevels of alpha-1 microglobulin, we found microalbuminuria in 12 out of 104 patients (11.5%). We observed correlation between microalbuminuria and the presence of cryoglobulinemia and circulating rheumatoid factor (p<0.01). The presence of cryoglobulinemia and rheumatoid factor in these individuals were related.to elevated levels ofhepatitis C vírus antibodies (p<0.05), ethnic background (non-white) (p<0.05), elevated levels of gamma-globulin (p<0.01) and of gamma-glutamyl transferase (p<0.01). We found no relation between the presence of microalbuminuria and serurn levels of alanineaminotransferase, either with decreased in C3 and C4 fractions of the serurn complemento Therefore we concluded thàt even in asymptomatic iIÍdividuals with normal renal and hepatic functions, the presence of microalbuminuria should be evaluated when rheumatoid factor and/or cryoglobulinemia are present in serum, with the purpose of identify initial renal disease

ASSUNTO(S)

nefrologia

ACESSO AO ARTIGO

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