Avaliação da glicemia de diabeticos sob tratamento odontologico com o uso de diazepam como medicação pre-anestesica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

The purpose of this study was to evaluate the effect of premedication with diazepam on blood glucose levels in diabetic and non-diabetic volunteers submitted to dental treatment and to verify the accuracy of a glucose meter (Advantage TRADE MARK ) when compared to the reference laboratorial method (GOD-PAP). Ten non-diabetics and 10 controlled diabetics taking oral hypoglycemic drugs were submitted to 3 study sessions, in a cross over and blinded manner. In the first session (basal), two fasting blood samples were taken to determine blood glucose concentration and glycosylated hemoglobin, and 5 blood samples to determine blood glucose concentration in the periods of 60, 80, 95, 125 and 155 minutes after breakfast. In the 2nd and 3rd sessions, the subjects were randomly given 5 mg diazepam or placebo during breakfast. One hour after breakfast a blood sample was taken and the volunteers were submitted to periodontal treatment after anesthesia infiltration with 1 cartridge of 2% mepivacaine and 1:100,000 adrenaline. The last 4 times of blood collection were 15, 30, 60 and 90 minutes after anesthesia (respectively 80, 90, 125 and 155 min after breakfast). Blood pressure and heart rate were assessed at each blood collection. The anxiety of the volunteers was analyzed by Corah dental anxiety scale in the last session. The results of blood glucose, blood pressure and heart rate were statistically analyzed in sub subdivided fragments and compared by the Tukey test (p<0.05). The results of anxiety were compared by the Mann-Witney test. Statistically significant differences in the blood glucose levels were observed between diabetic and nondiabetic volunteers. However, there were no significant differences among the sessions of the same group. Blood pressure, heart rate, and anxiety levei were not different between the groups. A positive correlation was observed for the methods of analysis of glycemia (Pearson s correlation coefficient = 0.95164). Under the conditions of this experiment, it can be concluded that the use of 5 mg diazepam before dental treatment does not interfere with blood glucose concentration of nondiabetics and controlled diabetics (taking oral hypoglycemic drugs) and that the glucose meter analyzed in this study (Advantage TRADE MARK ) is equivalent to the reference laboratorial method

ASSUNTO(S)

tranquilizantes doenças cronicas anestesicos monitorização de pacientes glicose

ACESSO AO ARTIGO

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