Avaliação da contaminação tumoral do trajeto da biópsia de tumores musculoesqueléticos malignos primários: estudo histopatológico / Evaluation of the tumoral seeding of the biopsy tract of primary malignant musculoskeletal tumors: histopathologic study

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Wide resection of biopsy tracts to tumors forms part of oncological surgical techniques because of the risk of tumor cell implantation and local and/or systemic disease recurrence. The aim of this study was to investigate the risk of seeding by neoplastic cells along biopsy tracts. This was a prospective histopathological study on biopsy tracts in 25 patients who underwent operations due to malignant musculoskeletal tumors, at the Institute of Orthopedics and Traumatology, School of Medicine of the University of São Paulo, between April 2006 and April 2007. Neoplastic cells were found implanted in 32% of the tracts. Correlation of the results from studying the tracts with the use of neoadjuvant chemotherapy did not present significant findings. This shows that, even with chemotherapy, the risk of implantation exists. The most common histological abnormalities in positive cases were classified as severe fibrosis, mild inflammatory component and severe neovascularization. We suggest that oncological resection of the tract should be carried out together with excision of the specimen

ASSUNTO(S)

soft tissue neoplasms/diseases neoplasias de tecidos moles/patologia biopsy neoplasias ósseas/patologia bone neoplasms/diseases sarcoma sarcoma biópsia

ACESSO AO ARTIGO

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