Atividade fagocitaria de macrofagos e celulas gigantes multinucleadas em granulomas induzidos por esponjas de policlorovinil

AUTOR(ES)
DATA DE PUBLICAÇÃO

1983

RESUMO

The granuloma induced by polyvinylchloride (PVC) sponge was used as an experimentalmodel to study the ar rival and the phagocitary activity of the macrophages and inflammatory multinucleate giant cells. It were used thirty (30) rats divided in two groups. In the first. group (I), the polyvinyl-chloride sponge was implanted in the dorsal subcutaneous tissue and considered as controlo In the second group (lI), the PVC sponge were impregnated uniformly by carbon particles and then implanted. Granulomata were removed at 3, 6, 10, 13, 17, 21, 24, 28, 31, 35, 38 and 45 days after the implantation of the sponges, fixedin 10% formalin and then submited to routine procedures, in order to obtain slices stained with haematoxylin and eosin. The number of macrophages and inflám¬màtpry multinucleate cells were determinated by counting isolated microscopic fields and by the total counting method where the whole lamina were observed. The results fron isolated microscopic field were not considered because there is impossibility to apply a statistical analysis. By the other ahand, tnose got fron the total counting method were submited to Pearson s coeficiente. The author observed that the macropha¬ges were present in granulamata since the 3rd day, increaing their quantity úntill the 28th and kept constant until the 45th day, in spite of small variations. The macrophage phagocitary activity was increasing as the granuloma evoluted, and the macrophages were concentrated in certain areas of the granuloina, what can suggest a possible action of a soluble factor present inthe inflammatory field which would influence their migration and proliferation.The multinucleated giant cells stated to appear in granulomata on the 10th day, increasing their number gradually until the 24th, and then kept constant until . the 45th day, with little variation. They presented moderated phagocitary activíty in all their evolutive phases, suggestlng the fusion of "old" with "young" or recently arrived macrophages fron the blood stream, in order to form an inflammatory multinucleate giant cell in the sponge induced granuloma.

ASSUNTO(S)

patologia bucal fogositose

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