Atividade de extratos de Arrabidaea chica (Humb. & Bonpl.) Verlot obtidos por processos biotecnológicos sobre a proliferação de fibroblastos e células tumorais humanas

AUTOR(ES)

Taffarello, Denise, Jorge, Michelle Pedroza, Sousa, Ilza Maria de Oliveira, Duarte, Marta Cristina Teixeira, Figueira, Glyn Mara, Queiroz, Nubia de Cassia Almeida, Rodrigues, Rodney Alexandre Ferreira, Carvalho, João Ernesto de, Goes, Ana Lucia Tasca Ruiz, Foglio, Mary Ann, Riveros, José Manuel, Eberlin, Marcos Nogueira, Cabral, Elaine Cristina

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2013

RESUMO

Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins. This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity. Anticancer activity in human cancer cell lines in vitro using a 48 h SRB cell viability assay was performed to determine growth inhibition and cytotoxic properties. The final extraction yield without enzyme treatment was higher (24.28%) compared to the enzyme-treated material (19.03%), with an enhanced aglycones anthocyanin ratio as determined by HPLC- DAD and LC-MS with direct infusion.

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