Atividade biolÃgica das lectinas de sementes de erythrina fusca e velutina, de algas marinhas hypnea musciformes, bryothamnion seaforthii e triquetrum e do produto natural diterpeno casbano, em culturas de pseudomonas aeruginosa / Biological activity of lectins from Erythrina velutina and fusca, seaweed Hypnea musciformes, bryothamnion seaforthii and triquetrum and casbano diterpene natural product, in cultures of Pseudomonas aeruginosa

AUTOR(ES)

Ricardo Hideo Togashi

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

24/02/2010

RESUMO

In this study the biological activity of seeds lectins from Erythrina velutina and fusca, marine algae Hypnea musciformis, Bryothamnion seaforthii and triquetrum and the diterpene casbane, a natural product isolated from Croton nepetaefolius was evaluated upon Pseudomonas aeruginosa ATCC 10145. We compared the in vitro effect of lectins and diterpene casbane on colonies of P. aeruginosa in microtiter plates. Investigated the action of lectins from marine algae H. musciforme of seeds of Erythrina velutina, and diterpeno casbano in the process of formation of P. aeruginosa biofilm on polystyrene plates, and identified among lectins: E. velutina, H. musciforme and diterpene casbane, the one with greater potential for application in controlling the growth of colonies of P. aeruginosa. The lectins tested were able to inhibit growth and biofilm formation of P. aeruginosa in the studied conditions. Moreover, diterpene casbane at a concentration of 500 mg/mL in 18 hours, was able to inhibit the growth of P. aeruginosa in 40%, compared to positive control. This inhibition was observed until a concentration of 125 mg/mL. However, the inhibition of biofilm formation of P. aeruginosa there was no observed at the concentrations used in this study.

ASSUNTO(S)

pseudomonas aeruginosa diterpeno lectina pseudomonas aeruginosa biologia geral agentes antibacterianos produtos biolÃgicos -uso terapÃutico infecÃÃes por pseudomonas diterpene lectin

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