ATIVIDADE ANTIMICROBIANA DE FRAÇÕES DE EXTRATOS E COMPOSTOS PUROS OBTIDOS DAS FLORES DE Acmela brasiliensis SPRENG (Wedelia paludosa) (ASTERACEAE) / ANTIMICROBIAL ACTIVITY OF EXTRACTS, FRATIONS AND PURE COMPOUNDS OF FLOWERS FROM Acmela brasiliensis SPRENG (Wedelia paludosa) (ASTERACEAE)

AUTOR(ES)

Mara Rúbia Keller Sartori

DATA DE PUBLICAÇÃO

2005

RESUMO

The growing number of immunocompromised patients in the last two decades, led to an increase in the incidence of microbial and fungal infections, which have become a major cause of morbidity or/and mortality. One of the most promising sources of new antimicrobial compounds are plants used in folk medicine for treating ailments related with the searched activity, in this case, plants used to treat infections. This approach is particularly interesting in Brazil, which possess a biodiversity very rich because of its tropical climate and a long tradition in the usage of medicinal plants. The selected plant in this study was the Acmela brasiliensis Spreng (Asteraceae), in the past classified as Wedelia paludosa DC, a native Brazilian medicinal plant used in folk medicine against several disorders, including infections of the respiratory tract, inflammations, and affections in general, reveled antimicrobial and antifungal activity. This work evaluated antimicrobial activity of frations of flowers extracts from A. brasiliensis, by dilution methods and revealed activity against Gram positives bacteria (Staphylococcus aureus and Bacillus cereus) and dermatophytes (Epidermophyton floccosum, Trichophyton rubrum and Trichophyton mentagrophytes). The hexane, dichloromethane and butanol fractions, showed activity, with minimum inhibitory concentration (MIC) between 250 and 1000 μg/mL. Two pure compounds showed antimicrobial activity. The kareunoic acid and luteolin showed activity against dermatophytes (MIC = 50 to 100 μg/mL and 125 to 250 μg/mL, respectably) and Gram positives (MIC = 500 to 800 μg/mL). The plant extracts (fractions hexane and dichoromethane) avaliable by microwell toxicity assay using Artemia salina showed no toxicity.

ASSUNTO(S)

plantas medicinais antifungal activity acmela brasiliensis luteolina wedelia paludosa kaurenoic acid acmela brasiliensis wedelia paludosa luteolin atividade antimicrobiana concentração inibitória mínima minimum inhibitory concentration ácido caurenóico farmacia

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