Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos

AUTOR(ES)

Paraginski, Gustavo Luiz, Berticelli, Claiton Roberto, Zambiazi, Priscilla Jussiani, Paraginski, Vanessa Teixeira Kunz, Hörner, Manfredo, Santos, Aline Joana Rolina Wohlmuth Alves dos, Hörner, Rosmari

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2014

RESUMO

Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC).

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