Aspectos de física estatística na evolução e no crescimento molecular. / Aspects of statistical physics on evolution and in molecular growth.

AUTOR(ES)

Wenderson Alexandre de Sousa Silva

DATA DE PUBLICAÇÃO

2009

RESUMO

Molecular Evolution, stimulated and supported by Evolution Synthetic Theory, became essential to understand evolution of life. Genomic growth was responsible to increase the capacity of storage information and to stability of the molecule; besides, it was also submitted to natural selection. Using amplification-mutation-selection methodology, such as SELEX (systematic evolution of ligands by exponential enrichment), and tools of Information Theory, it was developed computer program to simulate macromolecule evolution taking into account, besides other, a less study parameter in specialized journal: the genome size variation. It was studied two different scenarios. In the first one, selection was dependent of a specific sequence to be searched; moreover, Shannon entropy took into account all nucleotides of all molecules and it was studied with until two sequence target. It was possible develop an analytical equation to well describe simple settings of this model. In the second scenario, in another hand, selection depends on a specific sequence, but is not required to match the whole sequence. Also, to compute Shannon entropy it was taking into account only the least Hamming distance sequence of each molecule. It was studied until five sequence target in this scenario. Entropy was not significant in first scenario as it was in the second one. Size genome evolution shows the system were under compression selection, being necessary to get other advantage to become possible an increase in genome size.

ASSUNTO(S)

biotechnology statistical physics física estatística geometry and computational modeling evolução molecular genomas (crescimento e desenvolvimento) information theory genomes (growth and development) geometria e modelagem computacional molecular evolution mecânica estatística statistical mechanics sistemas complexos complex systems biotecnologia teoria de informação

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