Genomes Growth And Development
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Construction and characterisation of a complete reverse genetics system of dengue virus type 3
Dengue virulence and fitness are important factors that determine disease outcome. However, dengue virus (DENV) molecular biology and pathogenesis are not completely elucidated. New insights on those mechanisms have been facilitated by the development of reverse genetic systems in the past decades. Unfortunately, instability of flavivirus genomes cloned in E
Mem. Inst. Oswaldo Cruz. Publicado em: 11/10/2013
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2. Identificação e análise de sequências codificantes com atributos conflitantes em genomas procariotos / Analysis and identification of prokaryotic coding sequences with confliting atributes eng
The advent of new sequencing technologies and the development of computational tools that facilitate the analysis of genomes, generated the exponential growth of genome databases. New approaches in-silico of the comparative genomics use such data in its comparisons. Nevertheless, recent work on the genome of Escherichia coli indicate that the current state o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/08/2010
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3. Identificação e Análise de Sequências Codificantes com Atributos Conflitantes em Genomas Procariotos / Analysis and Identification of Prokaryotic Coding Sequences With Conflicting Atributes
The advent of new sequencing technologies and the development of computational tools that facilitate the analysis of genomes, generated the exponential growth of genome databases. New approaches in-silico of the comparative genomics use such data in its comparisons. Nevertheless, recent work on the genome of Escherichia coli indicate that the current state o
Publicado em: 2010
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4. Aspectos de física estatística na evolução e no crescimento molecular. / Aspects of statistical physics on evolution and in molecular growth.
Molecular Evolution, stimulated and supported by Evolution Synthetic Theory, became essential to understand evolution of life. Genomic growth was responsible to increase the capacity of storage information and to stability of the molecule; besides, it was also submitted to natural selection. Using amplification-mutation-selection methodology, such as SELEX (
Publicado em: 2009
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5. Expressão heteróloga, purificação e caracterização de proteínas transmembrana de Mycoplasma hyopneumoniae / Heterologous expression, purification and characterization of transmembrane protein of Mycoplasma hyopneumoniae
Mycoplasma hyopneumoniae is the etiological agent of swine enzootic pneumonia (EP), one the most common respiratory diseases of pigs worldwide. The disease is characterized by retarded growth rate in animals of mid-finishing to slaughter age, causing significant economic losses to swine production. Vaccination is the most cost-effective strategy for the cont
Publicado em: 2008
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6. Analise funcional do regulador de transcrição do tipo bZIP AtbZIP9 de Arabidopsis thaliana atraves da superexpressão de seus genes alvos / Fucntional characterization of the Arabidopsis thaliana bZIP transcription factor AtbZIP9 by overexpression of its target genes
Transcriptional regulatory factors (TFs) play an important role in controlling growth and development of ali organisms. bZIPs TFs have been described in ali eukaryotes and are characterized by a basic aminoacid rich DNA binding domain and a leucine zipper, responsible for dimerization. bZIPs have been reported to act in several different plantspecific proces
Publicado em: 2007
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7. Progress toward the development of a genetically engineered attenuated hepatitis A virus vaccine.
Mutations which positively affect growth of hepatitis A virus in cell culture may negatively affect growth in vivo. Therefore, development of an attenuated vaccine for hepatitis A may require a careful balancing of mutations to produce a virus that will grow efficiently in cells suitable for vaccine production and still maintain a satisfactory level of atten
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8. MorA Defines a New Class of Regulators Affecting Flagellar Development and Biofilm Formation in Diverse Pseudomonas Species
Assembly of bacterial flagella is developmentally important during both planktonic cell growth and biofilm formation. Flagellar biogenesis is complex, requiring coordinated expression of over 40 genes, and normally commences during the log-to-stationary transition phase. We describe here a novel membrane-localized regulator, MorA, that controls the timing of
American Society for Microbiology.
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9. Molecular and ultrastructural analysis of a nonchromosomal variegated mutant. Tomato mitochondrial mutants that cause abnormal leaf development.
Mutants were recovered in a population of cybrids formed following protoplast fusion between tomato (Lycopersicon esculentum Mill.) cv UC82 and Lycopersicon pennellii Corr. The cybrids were identified as individuals with recombinant cytoplasmic genomes but only tomato nuclear genomes. The mutants were identified based on two features, a variegated sectoring
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10. An Epstein–Barr-related herpesvirus from marmoset lymphomas
Epstein–Barr virus (EBV) is implicated in the development of human B cell lymphomas and carcinomas. Although related oncogenic herpesviruses were believed to be endemic only in Old World primate species, we now find these viruses to be endemic in New World primates. We have isolated a transforming, EBV-related virus from spontaneous B cell lymphomas o
The National Academy of Sciences.
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11. Expression Profiling and Comparative Genomics Identify a Conserved Regulatory Region Controlling Midline Expression in the Zebrafish Embryo
Differential gene transcription is a fundamental regulatory mechanism of biological systems during development, body homeostasis, and disease. Comparative genomics is believed to be a rapid means for the identification of regulatory sequences in genomes. We tested this approach to identify regulatory sequences that control expression in the midline of the ze
Cold Spring Harbor Laboratory Press.
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12. Human Telomerase and Its Regulation
The telomere is a special functional complex at the end of linear eukaryotic chromosomes, consisting of tandem repeat DNA sequences and associated proteins. It is essential for maintaining the integrity and stability of linear eukaryotic genomes. Telomere length regulation and maintenance contribute to normal human cellular aging and human diseases. The synt
American Society for Microbiology.