As contribuições de Alexander Fleming para o estudo da imunologia natural: 1908-1921

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

On the turn of the twentieth century, several scientists were investigating infectious diseases. The aim of this research is to rebuild the path followed by Alexander Fleming (1881-1955) in his studies on microbiology, from 1908 to 1921, when he identified an enzyme related to the natural immunology of living beings. This dissertation contains an introduction and five chapters. Chapter 1 deals with Flemings first bacteriological investigations, in cooperation with Almroth Wright (1861-1947). Besides that, it deals with Flemings prescriptions for skin infections. Chapter 2 analyses Flemings contributions concerning the SALVARSAN therapy. Chapter 3 presents Flemings research on the treatment of infected injures got during the First World War, as well as, the experiments on microorganisms performed by him. Chapter 4 describes Flemings research on secretions and tissues, concerning the identification of an important enzyme related to the natural immunology. Chapter 5 provides some final remarks on the subject. This study showed that Fleming was very cautious in methodological terms. It led to the conclusion that although Fleming had been trained under Wright and several of his contributions were part of a collective work, this was not the case concerning the identification of lysozyme. This Flemings original contribution changes the view that was accepted at that time

ASSUNTO(S)

lisozima imunologia -- historia wright, almroth -- 1861-1947 lisosima história da microbiologia fleming, alexander -- 1881-1955 lysozyme microbiologia -- historia historia das ciencias history of microbiology

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