Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
AUTOR(ES)
Sá, Marcus Mandolesi, Ferreira, Misael, Lima, Emerson Silva, Santos, Ivanildes dos, Orlandi, Patrícia Puccinelli, Fernandes, Luciano
FONTE
Braz. J. Microbiol.
DATA DE PUBLICAÇÃO
2014-09
RESUMO
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
Documentos Relacionados
- Morita-Baylis-Hillman na síntese de antitumorais
- A highly efficient and general method for the preparation of (Z)-allylic bromides derived from Morita-Baylis-Hillman adducts
- Morita-Baylis-Hillman Reaction with 7-Chloroquinoline Derivatives-New Compounds with Potential Anticancer Activity
- Synthesis of 2-oxazolidinones with potential antibacterial activity from Morita-Baylis-Hillman adducts
- Síntese assimétrica de pirrolizidinonas e pirrolizidinas substituídas a partir da reação de Morita-Baylis-Hillman