Antifungal Activity of Isothiocyanates and Related Compounds: III. Derivatives of Diphenyl, Stilbene, Azobenzene, and Several Polycondensed Aromatic Hydrocarbons

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This paper presents the results of a study on the antifungal activity of isothiocyanates—derivatives of biphenyl (group “A”), of stilbene (“B”), of azobenzene and benzeneazonaphthalene (“C”), of naphthalene (“D”), and of further polycondensed aromatic hydrocarbons (“E”). From a total of 48 investigated compounds, antifungal activity was observed only in A and D group compounds. B, C, and E group derivatives are extremely insoluble in water, and the molecules are very large; as a result, they probably cannot pass into spores or mycelium of fungi. Thus, the —NCS group cannot manifest its reactivity.

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