Antifungal Activity of Isothiocyanates and Related Compounds: I. Naturally Occurring Isothiocyanates and Their Analogues
AUTOR(ES)
Drobnica, Ľ.
RESUMO
Data are presented concerning the antifungal activity of 11 natural isothiocyanates and 27 synthetized analogues in Aspergillus niger, Penicillium cyclopium, and Rhizopus oryzae, as well as in 13 additional saprophytic and parasitic fungi. A remarkable antifungal activity was observed in some analogues of benzylisothiocyanate and β-phenylethylisothiocyanate. The latter-mentioned compounds have not been described previously. In the group of benzylisothiocyanates, a correlation, which was inversely proportional, was detected between ed100 values for A. niger and R. oryzae and the corresponding molar solubilities of compounds in water. In contradistinction, no relationship was observed between antifungal activity and chemical reactivity of investigated derivatives.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=547041Documentos Relacionados
- Antifungal Activity of Isothiocyanates and Related Compounds: II. Mononuclear Aromatic Isothiocyanates
- Antifungal Activity of Isothiocyanates and Related Compounds: III. Derivatives of Diphenyl, Stilbene, Azobenzene, and Several Polycondensed Aromatic Hydrocarbons
- Antimicrobial Properties of Natural Phenols and Related Compounds: I. Obtusastyrene
- Naturally Occurring Enzyme Activity Variation in DROSOPHILA MELANOGASTER. I. Sources of Variation for 23 Enzymes
- The Mode of Action of Nitrofuran Compounds: I. Action Versus Staphylococcus aureus