Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS

AUTOR(ES)

Gaffney, Vanessa de Jesus, Cardoso, Vitor Vale, Rodrigues, Alexandre, Ferreira, Elisabete, Benoliel, Maria João, Almeida, Cristina M. M.

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2014

RESUMO

A method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy. The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively. Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system. Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.

Documentos Relacionados

• Development of a rapid method for the determination of antibiotic residues in honey using UPLC-ESI-MS/MS
• Ensaios toxicológicos aplicados à análise de águas contaminadas por fármacos
• Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivatives in associated marine microorganisms from Eudistoma vannamei
• Investigation of phenolic profiles and antioxidant activities of some Salvia species commonly grown in Southwest Anatolia using UPLC-ESI-MS/MS
• Análise de efedrinas e anfetamina em urina empregando spe e spme por cg/em/em