Análise da associação dos polimorfismos IL1B (C+3954T) e IL1RN (intron 2) com a perda de implantes dentais osseointegráveis

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Dental implants have become an important therapeutical modality for tooth replacement. Although the high success rate showed in longitudinal studies, failures occur, even in patients who present appropriate clinical conditions. Together with the clusterization phenomenon, which is the presence of multiple implant losses in the same group of individuals, this fact suggests that host response aspects can influence the implant failure process. However, little is known about the influence of genetic susceptibility on implant loss. The aims of the present study were: i) identify clinical factors related to dental implant loss in patients from the Latin American Dental Research Institute (ILAPEO); ii) investigate the association between dental implant loss and the functional polymorphisms IL1B (+3954) and IL1RN (intron 2). In a retrospective analysis of 3,578 records, panoramic and periapical radiographs of patients who had placed implants in ILAPEO during the period of 1996 to 2006 were analyzed. Implant loss occurred in 126 (3.5%) patients. Men lost more implants 4 than women. The main clinical detectable causes of implant loss were evaluated. Failure was more frequent when the implant was installed in the posterior jaw. Most implant failure (75%) did not present apparent clinical cause. A sample of 266 patients was selected and divided in: Test group (T) - 90 subjects with implant loss, and Control group (C) - 176 subjects with at least one implant in function for at least six months. Patients socioeconomic profile, general medical condition, hygiene parameters, and clinical measurements such as number of teeth and periodontal status, were analyzed. Genomic DNA from oral mucosa was amplified by polymerase chain reaction (PCR). The fragments were submitted to agarose gel electrophoresis, followed by ethidiumbromide staining method. Polymorphisms IL1B (+3954) and IL1RN (intron 2) were in Hardy-Weinberg equilibrium. Regarding clinical aspects, the following parameters were observed to influence implant failure: edentulism, probing pocket depth, and number of present teeth. No differences in genotype distribution and allele frequencies between C and T groups were found for IL1B (+3954) and IL1RN (intron 2) polymorphisms in the study population. It was observed that clinical aspects, but not the study polymorphisms, were associated with osseointegrated dental implant loss.

ASSUNTO(S)

polimorfismo (genética) ciências médicas medicina implantes dentários osseointegrados

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