An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

AUTOR(ES)

Rivera, Gildardo, Bocanegra-Garcia, Virgilio, Moreno, Antonio, Galiano, Silvia, Pérez, Silvia, Aldana, Ignacio, Monge, Antonio

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2008

RESUMO

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

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