Activity of Daptomycin against Recent North American Isolates of Streptococcus pneumoniae

AUTOR(ES)

Restrepo, M. I.

FONTE

American Society for Microbiology

RESUMO

Daptomycin MICs at which 50% of isolates were inhibited (MIC50s) and MIC90s determined by the NCCLS broth microdilution method were both 0.25 μg/ml (range, 0.06 to 2 μg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.

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