Activities of Cethromycin and Telithromycin against Recent North American Isolates of Streptococcus pneumoniae

AUTOR(ES)

Jorgensen, James H.

FONTE

American Society for Microbiology

RESUMO

The in vitro activities of two investigational ketolides, cethromycin (formerly ABT-773) and telithromycin, were determined for a selected group of 312 Streptococcus pneumoniae isolates from a national surveillance program. The MIC of cethromycin at which 50% of the isolates were inhibited was 0.008 μg/ml, and the MIC at which 90% of the isolates were inhibited was 0.06 μg/ml; the corresponding values for telithromycin were ≤0.015 and 0.25 μg/ml, respectively. For six quinupristin-dalfopristin-resistant strains, the cethromycin MICs were 0.25 to 16 μg/ml and the telithromycin MICs were 1 to 4 μg/ml. However, there was only 0.3% resistance to telithromycin.

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