Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation
AUTOR(ES)
Saka, E.
FONTE
National Academy of Sciences
RESUMO
Interneurons are critical for shaping neuronal circuit activity in many parts of the central nervous system. To study interneuron function in the basal ganglia, we tested and characterized an NK-1 receptor-based method for targeted ablation of specific classes of interneuron in the striatum. Our findings demonstrate that the neurotoxin SP-PE35, a substance P–Pseudomonas exotoxin conjugate, selectively targets striatal cholinergic and nitric oxide synthase/somatostatinergic interneurons when injected locally into the striatum. The effects of this selective cell targeting encompassed alterations in both behavioral and neural responses to dopaminergic stimulation, including altered patterns of early-gene response in striosomes and matrix. We conclude that NK-1-bearing local circuit neurons of the striatum regulate the differential responses of striatal projection neurons to dopamine-mediated signaling.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=124413Documentos Relacionados
- Local Circuit Neurons
- Genetic control of number of midbrain dopaminergic neurons in inbred strains of mice: relationship to size and neuronal density of the striatum.
- Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
- Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
- Sites of Plasticity in the Neural Circuit Mediating Tentacle Withdrawal in the Snail Helix aspersa: Implications for Behavioral Change and Learning Kinetics