Abnormal hormone responses of an adrenocortical cancer adenyl cyclase

AUTOR(ES)

Schorr, Immanuel

RESUMO

Properties of adenyl cyclase of normal adrenals and of a corticosterone-producing adrenal cancer of the rat have been compared. Enzyme activity was found in all particulate fractions of both tissues. The cyclase of the tumor as well as of the adrenals was stimulated by adrenocorticotropic hormone (ACTH) over similar concentration ranges. Unexpectedly, the tumor enzyme was also stimulated by epinephrine, norepinephrine, and thyroid-stimulating hormone (TSH). These hormones produced a dose-related effect over a concentration span that was comparable with that for ACTH. The tumor cyclase was not responsive to angiotensin Il, vasopressin, glucagon, insulin, growth hormone, parathyroid hormone, and thyrocalcitonin. ACTH was the only hormonal preparation that stimulated normal adrenal cyclase. These findings are compatible either with the possibility that the adenyl cyclase receptor of the tumor has undergone structural alteration with a consequent loss of specificity for ACTH or with the possibility that the tumor possesses several cyclase regulatory receptors.

Documentos Relacionados

• Inhibition of Hormone-Sensitive Adenyl Cyclase by Phenothiazines
• Neurohypophyseal Hormone-Sensitive Adenyl Cyclase of Toad Urinary Bladder*
• Myocardial adenyl cyclase: activation by thyroid hormones and evidence for two adenyl cyclase systems
• ADENYL CYCLASE AND HORMONE ACTION, I. EFFECTS OF ADRENOCORTICOTROPIC HORMONE, GLUCAGON, AND EPINEPHRINE ON THE PLASMA MEMBRANE OF RAT FAT CELLS
• Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.