Neurohypophyseal Hormone-Sensitive Adenyl Cyclase of Toad Urinary Bladder*
AUTOR(ES)
Bär, Hans-Peter
RESUMO
An adenyl cyclase preparation derived from epithelial cells of the urinary bladder of the toad, Bufo marinus, is described. This cyclase preparation is specifically stimulated by neurohypophyseal hormones and various synthetic analogs which evoke a hydroosmotic response in the intact bladder. The relative stimulatory effects of these compounds have been compared on the cyclase preparation and in the intact bladder. The peptide concentrations required for half-maximal stimulation (affinity) in the cell-free and intact systems were parallel; however the magnitude of stimulation produced by saturating concentrations of peptides did not correlate. Furthermore, it was found that peptide analogs which inhibit the hydroosmotic effect of [8-arginine]-vasopressin on the intact bladder also inhibit the stimulation of the toad bladder cyclase preparation by vasopressin. Prostaglandin E1, mercaptans, and disulfides, which inhibit the hormone-induced hydroosmotic response of the intact bladder, did not antagonize the stimulation of the toad bladder cyclase preparation by vasopressin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283157Documentos Relacionados
- Inhibition of Hormone-Sensitive Adenyl Cyclase by Phenothiazines
- Regulation of hormone-sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells.
- Another hormone-sensitive triglyceride lipase in fat cells?
- Hormone-sensitive fat cell adenylate cyclase in the rat. Influences of growth, cell size, and aging.
- 3,3′,5-Triiodothyronine Administration In Vivo Modulates the Hormone-sensitive Adenylate Cyclase System of Rat Hepatocytes