A Straightforward Synthesis of Enantiopure (1S,2R)-Ephenamine
AUTOR(ES)
Velho, Arthur C. C.; Martins, José E. D.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2020-12
RESUMO
An enantioselective six-step synthesis of (1S,2R)-ephenamine starting from readily available chiral amino acid is disclosed presenting 26% overall yield and high optical purity. The use of chiral phenylglycine as starting material was also studied and did not present satisfactory results due to a very sensitive a-carbonyl/benzylic stereogenic center that, in our hands, led to racemization.
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