A Interleucina 1 beta desempenha um papel termogênico na inflamação hipotalâmica induzida por dieta em ratos / Interleukin 1 beta plays a thermogenic role in diet-induced hypothalamic inflammation

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

15/03/2011

RESUMO

In experimental obesity, changes in hypothalamic function play an important role in the anomalous regulation of food intake and energy expenditure. Recent studies have shown that a low-grade hypothalamic inflammation is an important factor contributing to hypothalamic dysfunction in this context. Cytokines such as TNF alfa , IL6 and IL10 have been studied in the hypothalamus of experimental models of obesity, however, the role played by IL1? in this condition is unknown. Here we employed small-intereference RNA conjugated with the rabies virus RVG-9R peptide to deliver an IL1? antisense RNA to the central nervous system. This approach led to a 50% reduction of hypothalamic expression of IL1? in obese rats and produced an increase in body mass gain without affecting food intake and spontaneous physical activity. Upon central nervous system IL1? inhibition the brown adipose tissue activity of the respiratory chain mitochondria enzyme citrate synthase was reduced, while the expression of PGC1 alfa ? was increased. Thus, the expression of IL1? in the hypothalamus of obese rats provides a brown adipose tissue-dependent thermogenic mechanism that protects against excessive body mass gain.

ASSUNTO(S)

obesidade hipotálamo interleucina-1 beta obesity hypothalamus interleukin-1beta

ACESSO AO ARTIGO

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