A influência do desafio com o parasita homólogo sobre a patologia cardíaca durante a fase crônica da infecção pelo T. cruzi. / The influence of the challenge with the parasite homologous on the heart disease during the chronic stage of infection by T. cruzi.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Chagas disease caused by Trypanosoma cruzi frequently results in chronic myocarditis that may result in death. The mechanisms underlying cardiac pathology are not totally clear. Our working hypothesis was that challenge could increase the immune systems effector activity against T. cruzi, leading to reduction in systemic and local parasite loads, which in turn could result, at the long run, in pathology diminution. The hystopathological analysis revealed that sustained challenge led to a small, but significant, decrease in heart pathology. These results could help to elucidate the etiopathogeny of chagasic heart lesions, inasmuch as they support the hypothesis of reactivity towards locally-persisting parasites. More important, our results open a hopeful perspective for the treatment of patients at the chronic phase.

ASSUNTO(S)

t cd4 lymphocytes trypanosoma cruzi cardiac pathology chagas disease linfócitos t cd8 t cd8 lymphocytes trypanosoma cruzi linfócitos t cd4 doença de chagas patologia clínica

ACESSO AO ARTIGO

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