Antitumour Activity
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. In vitro anticancer and antioxidant potential of Amaranthus cruentus protein and its hydrolysates
Abstract New insights on the use of peptides as therapeutic agents in the treatment of cancer have emerged with reports showing anti-tumour activity of peptides, predominantly derived from animals or microorganisms. Amaranth is a pseudocereal traditionally acknowledged to possess pharmacotherapeutic properties. Thus, the aim of this study was to compare the
Food Sci. Technol. Publicado em: 2020-12
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2. Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.
Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and E
Mem. Inst. Oswaldo Cruz. Publicado em: 16/01/2015
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3. Derivados oleananos e ursanos e sua importância na descoberta de novos fármacos com atividade antitumoral, anti-inflamatória e antioxidante
Oleanolic and ursolic acids are triterpenes that exist abundantly in the plant kingdom. They show antitumor activity and their cytotoxic activity was already evaluated against a broad range of cell lines. The inhibition of enzymes involved in the metabolism of DNA and the induction of apoptosis are known events that have been related to the antitumour activi
Química Nova. Publicado em: 2009
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4. Genetic diversity analysis by MLSA and antitumoral activity evaluation of Chromobacterium sp. strains. / Análise da diversidade genética por MLSA e avaliação da atividade antitumoral de linhagens de Chromobacterium sp.
A diversidade genética dos isolados de Chromobacterium sp. foi avaliada por Multilocus sequence analysis com base nas análises dos genes conservados rpoA, lepA, gyrB, fusA e rRNA 16S. A análise do gene rRNA 16S e MLSA agrupou os isolados no gênero Chromobacterium, entretanto, cinco dos isolados estão distantes filogeneticamente das linhagens tipo, C. vi
Publicado em: 2009
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5. 2-Acylcyclohexane-1,3-diones from Peperomia trineura (Miq.) / 2-Acil-cicloexano-1,3-dionas de Peperomia trineura (Miq.)
The crude extract of whole plant (Peperomia trineura) was subjected to adsorption chromatography on silica gel, preparative thin-layer chromatography (CCDP) and semi-preparative HPLC, resulting in the isolation of five novel polyketides with variable chain lenght or presence of unsaturation in the alkyl chain. The structural elucidation of these compounds wa
Publicado em: 2009
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6. Perfil FarmacolÃgico e ToxicolÃgico de Produtos Bioativos Obtidos de Streptomyces spp Isolados do Leito de Rios do Estado da ParaÃba
Aimed to search for species of Streptomyces isolated from mesoregions of Paraiba producers of bioactive metabolites with pharmacological activity, assessing the levels of toxicity of extracts and their chemical composition. 49 species of the genus Streptomyces were isolated from 68 samples of soil bed in the main rivers in different mesoregiÃes the state of
Publicado em: 2009
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7. Estudo fitoquÃmico e biolÃgico da hyptis mutabilis salz:(lamiaceae) / Phytochemistry and biological study of hyptis mutabilis
Crude extract of different parts of Hyptis mutabilis obtained using solvent of different polarities were submitted to the anti-microbial screening against 21 microorganisms from Departmental collection and clinically isolated to select the one with largest activity for phytochemistry studies. For MIC determination the extracts that presented halos above 14 m
Publicado em: 2003
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8. ObtenÃÃo, caracterizaÃÃo e avaliaÃÃo microbiolÃgica de uma nova forma farmacÃutica contendo hidroquinona
Hydroquinone (HQ) is a drug reported to possess manifold biological activities, such as depigmenting, antimicrobial and antitumour properties. The PluronicLecithin Organogel (PLOme) is a phospholipidic microemulsion particularly implied when a high cutaneous permeability and systemic absorption of a drug is suitable. Once that HQ is highly unstable i
Publicado em: 2003
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9. Cytotoxic and Antiviral Activities of Colombian Medicinal Plant Extracts of the Euphorbia genus
Forty-seven plant extracts of 10 species of the genus Euphorbia (Euphorbiaceae) used by Colombian traditional healers for the treatment of ulcers, cancers, tumors, warts, and other diseases, were tested in vitro for their potential antitumour (antiproliferative and cytotoxic) and antiherpetic activity. To evaluate the capacity of the extracts to inhibit the
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-06
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10. alpha-Tocopherol enhances tumour growth inhibition by cis-dichlorodiammine platinum (II)
Present studies indicate that alpha-tocopherol enhances the efficacy of cisplatin as demonstrated by inoculation of Dalton's lymphoma cells incubated with either cisplatin (5 or 10 µg/ml) alone or cisplatin + alpha-tocopherol (25 or 50 µg/ml) into C3H/He mice. Tumour cells (3 x 10(6) cells/mouse) incubated with cisplatin grow slowly in syngeneic mice as in
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-08
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11. T-regulatory cell modulation: the future of cancer immunotherapy?
T-regulatory cells suppress anti-tumour immunity in cancer patients and in murine tumour models. Furthermore, their activity is likely to have an effect on the effectiveness of immunotherapeutic treatments for cancer. Here we describe the current status of developing clinical strategies for modulating Treg activity in cancer patients.
Nature Publishing Group.
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12. Interaction of the antitumour drug 4'-(9-acridinylamino)-methanesulfon-m-anisidine.HCl (m-AMSA) with nucleic acids.
The interaction of AMSA with nucleic acids was studied by several techniques. Melting temperature and CD studies equally suggest that AMSA-binding is interfering with the secondary structure of DNA. An overlap by two mechanism of binding seems to exist. Based on the CD measurements at low drug concentration intercalation is the most likely way of binding. At